Yes of course via express.js and railway and several other frameworks. Again node itself is just a set of libraries on top of of v8. So its not a proper comparison.

Personally i use express.js and roll my own framework essentially because i prefer to work that way.

There's are some web frameworks that are aspiring towards Django/Rails-style, but none that have a similar ecosystem of plugins and developers yet.

The most popular web framework, express.js, is a bit more lower level, and is similar to Werkzeug from Python or Sinatra from Ruby.