Empirical observations about your own performance are inherently flawed while not on a mind-altering drug, barring measurement/metrics. If you're measuring, I can't imagine how your state of mind could affect those.

If you want good separation, find a metric that can be recorded/played back.

I thought we were hackers? There are obvious solutions here...

It can be hard enough to make empirical observations about one's own performance even when not under the influence of a mind-altering drug.

I did once spend an afternoon making recordings of myself playing guitar at different levels of sobriety. Results pretty much as expected :->.